NecstGen obtains €2 Million from Province South Holland

NecstGen obtains €2 Million from Province South Holland

NecstGen obtains €2 Million from Province South Holland

Today, Meindert Stolk, deputy Economy and Innovation of the Province South Holland visited NecstGen to hand over a symbolic cheque of € 2 million to Paul Bilars, CEO of NecstGen. Throughout the last years, the province has been closely involved with developments at the Leiden Bio Science Park. This included investments in facilities, networks and collaborations. The € 2 million subsidy has been awarded to support the establishment of NecstGen’s facility at the Leiden Bio Science Park. At this facility, academic and industrial clients can make use of state-of-the-art labs and cleanrooms to develop and produce regenerative therapies.

 

56 million euro from Dutch ‘Groeifonds’ to pilot factory for regenerative therapies

56 million euro from Dutch ‘Groeifonds’ to pilot factory for regenerative therapies

56 million euro from Dutch ‘Groeifonds’ to pilot factory for regenerative therapies

Today, the Dutch cabinet announced the investment of €56 million into the establishment of a “pilot factory” for regenerative therapies. NecstGen and three other facilities will form a chain covering the development and manufacturing of cell therapies, biomaterials, microtissues and macrotissues. The funding is awarded to RegMed XB, a collaboration of research institutes, governments, provinces, health funds, and industry in the Netherlands and Flanders aimed at the development of regenerative therapies and technologies.

Paul Bilars, CEO of NecstGen: “I am very excited about this investment in NecstGen. It will support us in our ambition to advance the development and manufacturing of promising regenerative therapies. We look forward to further strengthen the ecosystem of regenerative medicine in the Netherlands together with our RegMed XB-partners.”

“This pilot factory can focus on an underserved group of therapy developers: academic institutes and small companies.” Sander van Deventer, strategic advisory board member of NecstGen, further adds. “The investment thereby contributes to the continuation of a great pipeline that has been build up in and around the Netherlands”.

NecstGen will be supported by its local partners LUMC, Leiden University and Provincie Zuid-Holland and is currently building its GMP facility at the Leiden Bio Science Park. The company will open its doors in 2022.

Markwin Velder joins strategic board of NecstGen

Markwin Velder joins strategic board of NecstGen

Markwin Velder joins strategic board of NecstGen

NECSTGEN announces the addition of Markwin Velders to its strategic advisory board. Markwin Velders brings almost 20 years of experience as entrepreneur in the field of cell and gene therapy. He is Chairman of HollandBIO and co-founder of various biotech companies. As VP Operation at Kite Pharma, he led the establishment of a large scale CAR-T manufacturing site, after Kite’s acquisition by Gilead.

 

“NECSTGEN can play a crucial role in the development of new cell and gene therapies, and thereby provide a solution to numerous patients. It offers a solution to many researchers and young companies with revolutionary therapies. This field holds great potential and I am excited to join in making the company’s ambition a reality.”

 

Dr. Markwin Velders obtained his PhD in molecular immunology at Leiden University and worked as post-doc and assistant professor at Loyola University, authoring over 40 peer reviewed papers. He was CSO at AM-Pharma, a biopharma company developing treatment for acute kidney injury. Markwin subsequently joined TNO, where he held positions as Operations Manager and Business Unit Manager. In 2013, he was involved in NKI spin-off T-Cell Factory. There he played a crucial role in its acquisition by Kite Pharma. He was also CEO of SomantiX, a biotech company developing on angiogenesis inhibitors. From 2015 until 2020, Markwin Velders worked as Vice President Operations at Kite Pharma. In this period he established the company’s EU headquarters and built the organization from 3 until 300+ employees. After the company’s acquisition by Gilead, in 2017, Markwin headed the establishment of its CAR-T commercial manufacturing site, in Hoofddorp. He played a key role in the clinical advancement and commercial launch of its therapies in Europe. As of 2017 he is chairman of the board of HollandBIO, the association of Dutch biotech companies. He is also supervisory board member at Amarna Therapeutics, a Dutch gene therapy developer, and ISA Pharmaceuticals, a clinical stage immunotherapy company. Markwin Velders brings over 19 years of experience at leading positions in various biotech companies. He combines scientific and commercial experience, specifically in the field of cell and gene therapy.

Sander van Deventer joins strategic advisory board of NecstGen

Sander van Deventer joins strategic advisory board of NecstGen

Sander van Deventer joins strategic advisory board of NecstGen

NECSTGEN announces the appointment of Sander van Deventer to its strategic advisory board. Sander van Deventer adds both scientific as well as commercial expertise in the field of cell and gene therapy. He is professor of Translational gastroenterology at the Leiden University Medical Center and partner at venture capital firm Forbion. Among others, he co-founded gene therapy developer uniQure and played a crucial role in the commercialization of the first gene therapy Glybera.

“There is a lack of early phase development and manufacturing capacity, in The Netherlands. Hence, we are in danger of falling behind internationally. I am happy to support NECSTGEN’s vision, to answer to this clear market need and advance the field of cell and gene therapy.” Says Prof. van Deventer.

Prof. van Deventer is certified internist and gastroenterologist. He received his medical doctorate from the University of Amsterdam, and worked as a scientist in the Laboratory for Medical Biochemistry, Rockefeller University, New York. He was the first to administer the first commercial monoclonal antibody (Remicade®) to patients with Crohn’s disease. Also he had a critical role in the development of other therapeutic interventions, targeting cytokines, cytokine receptors, T‐cells and signal transduction pathways, using small molecules, antibodies, peptides, proteins and antisense DNA technologies. He supervised the development of Glybera, the first gene therapy product to be approved in Europe, and several other gene therapy products. In 1995, he became director of the laboratory for Experimental Internal Medicine at the Academic Medical Center in Amsterdam. In 1998 Prof. van Deventer co-founded uniQure B.V., developing AAV-based gene therapy products and now listed on Nasdaq, acting subsequently as CSO, CMO and CEO. He furthermore headed Dezima Pharma, that was later acquired by Amgen. From 2001 until 2004, he chaired the Department of Gastroenterology and Hepatology at the Academic Medical Center in Amsterdam. In 2006, Sander van Deventer co-founded as Managing Partner and subsequently as Operating Partner the venture capital firm Forbion Capital Partners. Until recently, he served on the scientific advisory boards of Argos, Engene, Staten and Hookipa Pharma. Since 2018, he is professor of Translational Gastroenterology at the Leiden University Medical Center, authoring over 400 peer-reviewed scientific papers.

NecstGen Teams up with IT-partner LINKIT

NecstGen Teams up with IT-partner LINKIT

NecstGen Teams up with IT-partner LINKIT

NECSTGEN has started a collaboration with IT-partner LINKIT. NECSTGEN is a spin out of the Leiden University Medical Center that will support clinicians, academic groups and small industrial therapy developers globally to bring cell and gene therapies to patients.

Paul Bilars, CEO of NECSTGEN: “LINKIT adds valuable knowledge and expertise the IT aspects of this field to the team. We are happy to join forces to make our shared vision possible.”

While NECSTGEN is preparing for its new development and GMP production facility to go live in 2022, it closely collaborates with LINKIT on realising a fitting IT roadmap. Sprint by sprint, and in compliance to GMP guidelines.

The project is being carried out by Jan Paul Buijs, Kees Mensch and Maaike Stoops from LINKIT.

Jan Paul Buijs adds: “Since the start of this collaboration, we feel like being part of the NECSTGEN team and its mission to bring cell and gene therapies to patients. We are happy to contribute to this exciting project!”

Launch of NecstGen in Leiden, The Netherlands

Launch of NecstGen in Leiden, The Netherlands

Launch of NecstGen in Leiden, The Netherlands

We are happy to announce the official launch of the Netherlands Center for the Clinical Advancement of Stem Cell & Gene Therapies (NECSTGEN). The new center has been established to accelerate the development and clinical realization of cell and gene therapies. Over the next two years NECSTGEN will create brand new facilities in Mirai House on the Leiden Bio Science Park, in The Netherlands. NECSTGEN is a wholly owned subsidiary of Leiden University Medical Center (LUMC).

Research and investment both public and private into cell and gene therapies has rapidly expanded and achieved the first therapies for patients. The potential of advanced therapies to alleviate suffering and support ageing societies is well known. The pace of expansion in the field has in some areas exceeded the capacity both of supply and available expert people to support every new therapy to the clinic affordably. Therefore NECSTGEN will in one location offer the expertise and facilities to support cell and gene therapy organizations, academic, clinical or start-up companies, in the Netherlands and internationally.

NecstGen will create a state-of-the-art research and development center to expedite cell and gene therapies. In addition a GMP facility with class B and class C cleanrooms will be constructed to produce for clinical trials and therapies. Mirai House is currently part occupied by the pharmaceutical company Astellas which has recently agreed to lease vacant space to LUMC to house NECSTGEN.

Located in Leiden, one of Europe’s leading scientific ecosystems in the field of advanced therapies, NECSTGEN will closely collaborate with academia and industry building on strong collaborations with organizations such as RegMedXB and the Center for Commercialization of Regenerative Medicine (CCRM) in Canada and Australia.

‘The development of regenerative and gene therapies will change the way patients are treated. We hope by playing our part and supporting the clinical advancement of this new generation of therapies, to help make difference in patients’ lives.’  Says Paul Bilars, CEO, NECSTGEN.

Cell Therapy Manufacturing & Development

Viral Vector Manufacturing & Development

Cleanroom Rental