Table of Approved ATMPs
Webinar: Scale-up Principles for Viral Vector Production
Scale-up Principles for Viral Vector Production
Scaling viral vector production from a few litres to larger stirred bioreactors is rarely a simple volume jump. Oxygen transfer, mixing, shear and power input all start to interact in ways that can affect yield, CQAs and overall process robustness.
What you’ll learn
You will explore the main engineering challenges of scaling stirred bioreactors for viral vectors and compare oxygen transfer via surface aeration and sparging, with a focus on how each approach impacts cells and productivity.
Lodewijk will discuss the factors that drive oxygen mass transfer rates, how to interpret and use kLa, and how power input can be used to balance oxygen transfer, mixing and shear instead of optimising them in isolation. The webinar will address shear from both agitation and aeration, along with practical protection strategies for shear-sensitive products.
Finally, you will see how oxygen transfer characterisation, scale-up criteria, scale-down models and DoE studies come together to de-risk decisions and support smoother tech transfer.
Register now
If you work in process development, MSAT or manufacturing and want a clearer, quantitative basis for your viral vector scale-up strategy, this session is for you.
Register now to secure your place and bring your questions on bioreactor design, oxygen transfer and shear control.
