Bioreactor Scale-up Principles for Viral Vector Production
Scaling viral vector production from development scale to larger stirred-tank bioreactors requires more than increasing volume. Parameters such as oxygen transfer, mixing, shear forces, and power input interact in ways that directly influence yield, critical quality attributes, and overall process performance. In this technical webinar, NecstGen shares a structured approach to scale-up based on engineering principles.
If you missed the live session, you can now watch the full webinar on demand.
What you’ll learn:
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How oxygen transfer changes with scale and how to compare surface aeration and sparging strategies in viral vector processes.
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How to interpret and apply kLa as a practical scale-up parameter rather than a theoretical value.
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How power input influences mixing, oxygen transfer, and shear, and how to balance these parameters during scale-up.
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How agitation and aeration contribute to shear stress, particularly for shear-sensitive viral vectors.
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How to approach scale-up decisions systematically to support reproducibility and GMP-readiness.
This replay is relevant for process development scientists, engineers, and manufacturing teams who want to strengthen the technical foundation of their viral vector scale-up strategy and reduce variability when moving toward GMP production.
If you have additional questions, we invite you to share your questions.
